Publications Archive - Schepartz Laboratory at UC Berkeley

2021

Initiating protein synthesis with noncanonical monomers in vitro and in vivo

J.M. Tharp, J.A. Walker, D. Söll, and A. Schepartz, Meth. Enzymol. 2021, in press https://doi.org/10.1016/bs.mie.2021.05.002

Cytosolic Delivery of Argininosuccinate Synthetase Using a Cell-Permeant Miniature Protein

S. Knox, R. Wissner, S. Piszkiewicz, and A. Schepartz, ACS Cent. Sci. 2021, in press https://doi.org/10.1021/acscentsci.0c01603

Genetic Encoding of Three Distinct Noncanonical Amino Acids Using Reprogrammed Initiator and Nonsense Codons

J. Tharp, O. Vargas-Rodriguez, A. Schepartz, and Dieter Soll. ACS Chemical Biology 2021, 16 (4) 766–774 https://doi.org/10.1021/acschembio.1c00120

Allosteric Inhibition of the Epidermal Growth Factor Receptor

J. K. L. Sinclair, W. E. Robertson, D. Mozumdar, K. Quach, and Alanna Schepartz. Biochemistry 2021, 60 (7) 500–512 https://doi.org/10.1021/acs.biochem.0c00978

2020

Structure of the bacterial ribosome at 2 Å resolution

Watson, Z. L.; Ward, F. R.; Meheust, R.; Ad, O.; Schepartz, A.; Banfield, J. F.; Cate, J. H. eLife 2020, 9. https://www.ncbi.nlm.nih.gov/pubmed/32924932

Discrete coiled coil rotamers form within the EGFRvIII juxtamembrane domain

D. Mozumdar, A. Doerner, J. Zhang, D. Rafizadeh & A. Schepartz, Biochemistry 2020, 59 (41) 3965-3972 https://doi.org/10.1021/acs.biochem.0c00641

Two-color nanoscopy of organelles for extended times with HIDE probes

L. Chu, J. Tyson, J.E. Shaw, F. Rivera-Molina, A.J. Koleske, A. Schepartz, & D.K. Toomre, Nat. Commun. 2020, 11 (1), 4271. https://www.nature.com/articles/s41467-020-17859-1

RNA sectors and allosteric function within the ribosome

A.S. Walker, W.P. Russ, R. Ranganathan, & A. Schepartz, Proc. Natl. Acad. Sci. 2020, 117 (33) 19879-19887. https://doi.org/10.1073/pnas.1909634117

Quantification of protein delivery in live cells using fluorescence correlation spectroscopy

S.L. Knox, A. Steinauer, G. Alpha-Cobb, A. Trexler, E. Rhoades, & A. Schepartz, Meth Enzymol 2020, 641, 477-505. https://doi.org/10.1016/bs.mie.2020.05.007

Endosome motility defects revealed at super-resolution in live cells using HIDE probes

A. Gupta, F. Rivera-Molina, Z. Xi, D. Toomre, A. Schepartz, Nat. Chem. Bio. 2020, 16 (4), 408-414. https://doi.org/10.1038/s41589-020-0479-z

Initiation of protein synthesis with non‐canonical amino acids in vivo.

J.M. Tharp, O. Ad, K. Amikura, F.R. Ward, E.M. Garcia, J.H.D. Cate, A. Schepartz, D. Söll
Angew. Chem. 2020 https://doi.org/10.1002/anie.201914671

2019

Dan Kahne: Winner of the 2019 Gordon Hammes Lectureship

A. Schepartz, Biochemistry 2019, 58, 3407.

Defects in the assembly of ribosomes selected for β-amino acid incorporation.

F.R. Ward, Z.L. Watson, O. Ad, A. Schepartz, & J.H.D. Cate, Biochemistry 2019, 58, 45, 4494-4504 doi: https://doi.org/10.1101/733584.

Translation of diverse aramid- and 1,3-dicarbonyl-peptides by wild type ribosomes in vitro.

Ad, K. Hoffmann, A. Cairns, A. Featherston, S.J. Miller, D. Söll, & A. Schepartz, ACS Cent. Sci. 2019, 5, 1289-1294.

Two-color nanoscopy of organelles for extended times with HIDE probes.

Chu, J. Tyson, J.E. Shaw, F. Rivera-Molina, A.J. Koleske, A. Schepartz*, & D.K. Toomre*, submitted. Bioxriv 2019: doi: https://doi.org/10.1101/647065.

Lessons in multi-institution teamwork using collaboration software.

S.G. Gaffney, O. Ad, S. Smaga, Z. Zhang, A. Schepartz, & J.P. Townsend, ACS Cent. Sci. 2019, 5, 1159-1169.

Labeling strategies matter for super-resolution microscopy: A comparison between Halo- and SNAP-Tags

R.S. Erdmann, S.W. Baguley, J.H. Richens, R.F. Wissner, Z. Xi, E.S. Allgeyer, S. Zhong, A.D. Thompson, N. Lowe, R. Butler, J. Bewersdorf, J.E. Rothman, D. St Johnston, A. Schepartz, & D. Toomre. Cell Chem Biol 2019, 26, 584–592.

HOPS-dependent endosomal fusion required for efficient cytosolic delivery of therapeutic peptides and small proteins.

A. Steinauer, J.R. LaRochelle, S.L. Knox, R.F. Wissner, S. Berry, & A. Schepartz, Proc Natl Acad Sci USA 2019, 116, 512.

2018

Special Issue on Discovering New Tools.

Schepartz. Biochemistry 2018, 57, 4605.

Synthesis and Biological Evaluation of an Indazole-Based Selective Protein Arginine Deiminase 4 (PAD4) Inhibitor.

Tjin, R. Wissner, H. Jamali, A. Schepartz, & J. Ellman, ACS Med Chem Lett 2018, 9, 1013.

Pushing the limits of solid-phase synthesis with continuous flow.

A.J. Mijalis, A. Steinauer, A. Schepartz, & B.L. Pentalute, Science of Synthesis: Flow Chemistry, Section 12, 2018, in press. DOI: 10.1055/sos-SD-228-00230

Fluorescence correlation spectroscopy reveals efficient cytosolic delivery of protein cargo by cell-permeant miniature proteins.

R.F. Wissner, A. Steinauer, S.L. Knox, A.D. Thompson, & A. Schepartz, ACS Cen Sci 2018, 4, 1379.

Introducing the Future of Biochemistry.

Schepartz. Biochemistry 2018, 57, 1.

Mechanism of allosteric coupling into and through the plasma membrane by EGFR.

J.K.L. Sinclair, A.S. Walker, A.E. Doerner, & A. Schepartz, Cell Chem. Biol. 2018, 857.

Rapid Phenolic O-Glycosylation of Small Molecules and Complex Unprotected Peptides in Aqueous Solvent.

T.J. Wadzinski, A. Steinauer, L. Hie, G. Pelletier, A. Schepartz & S.J. Miller, Nat. Chem. 2018, 10, 644-652. Highlight: Hitting the sweet spot, Nat Chem 2018, 10, 578-580; Stop Ignoring the Sugars, In the Pipeline (http://blogs.sciencemag.org/pipeline/archives/2018/05/07/stop-ignoring-the-sugars)

Foldamers wave to the ribosome.

Schepartz, Nat. Chem. 2018, 10, 377-379.

Unique arginine array improves cytosolic localization of hydrocarbon-stapled peptides.

Quach, J. LaRochelle. X-H. Li, E. Rhoades, A. Schepartz, Bioorg Med Chem 2018, 26,1197-1202.

2017

The ecstasy and agony of assay interference compounds.

Aldrich et al, J. Med, Chem. 2017, 60, 2165-2178.

Long-term live-cell STED nanoscopy of primary and cultured cells with the plasma membrane HIDE probe Dil-SiR.

A.D. Thompson, M.H. Omar, F. Rivera-Molina, Z. Xi, A.J. Koleske, D. Toomre, & A. Schepartz, Angew. Chem. 2017, 56, 10408-10412.

Long time-lapse nanocopy with spontaneously blinking membrane probes, Nature Biotechnology.

Takakura, Y. Zhang, R.S. Erdmann, A.D. Thompson, Y. Lin, B. McNellis, F. Rivera-Molina, S.N. Uno, M. Kamiya, Y. Urano, J.E. Rothman, J. Bewersdorf, A. Schepartz, & D. Toomre, Nat. Biotechnol. 2017, 35, 773-780. Highlight: Nanoscopic imaging that lasts, Nat Methods 2017, 14, 833.

STED imaging of Golgi dynamics with CerSiR: a two-component, photostable, high-density lipid probe for live cells.

R.S. Erdmann, D. Toomre, & A. Schepartz, Super-Resolution Microscopy: Methods and Protocols. 2017, in press.

A novel physiological role for ARF1 in the formation of bi-directional tubules from the Golgi.

Bottanelli, N. Kilian, A.M. Ernst, F. Molina-Rivera, L.K. Schroeder, E.B. Kromann, M.D. Lessard, R.S. Erdmann, A. Schepartz, D. Baddeley, J. Bewersdorf, D. Toomre, & J.E. Rothman, Mol. Biol. Cell. 2017, 28, 1676-1687.

2016

Building on 50 years of excellence where chemistry meets life science.

Schepartz, Biochemistry 2016, 55, 4997.

Rotamer-restricted fluorogenicity of the bis-arsenical ReAsH.

A.S. Walker, P.R. Rablen, & A. Schepartz, J. Am. Chem. Soc. 2016, 138, 7143-50. Highlight: Chosen for cover image.

β-peptide bundles: design. build. analyze. biosynthesize.

P.S. Wang & A. Schepartz, Chem. Commun. 2016, 52, 7420-32.

In vivo biosynthesis of a β-amino acid-containing protein.

Melo Czekster, W.E. Robertson, A.S. Walker, D. Söll, & A. Schepartz, J. Am. Chem. Soc. 2016, 138, 5194-7.

Aqueous glycosylation of unprotected sucrose employing glycosyl fluorides in the presence of calcium ion and trimethylamine.

Pelletier, A. Zwicker, C. Allen, A. Schepartz, & S. Miller, J. Am. Chem. Soc.2016, 138, 3175–3182.

Two-colour live-cell nanoscale imaging of intracellular targets.

F. Bottanelli, E.B. Kromann, E.S. Allgeyer, R.S. Erdmann, S.W. Baguley, G. Sirinakis, A. Schepartz, D. Baddeley, D.K. Toomre, J.E. Rothman, & J. Bewersdorf, Nat. Commun. 2016, 7, 10778. Highlight: F1000Prime (http://f1000.com/prime/726190331)

2015

Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo.

Li, Y. Tao, Y. Shu, J.R. LaRochelle, A. Steinauer, D. Thompson, A. Schepartz, Z.-Y. Chen, & D. Liu, J. Am. Chem. Soc. 2015, 137, 14084-93.

Improved carbohydrate recognition in water with an electrostatically enhanced β-peptide bundle.

M.S. Melicher, A.S. Walker, J. Shen, S.J. Miller, & A. Schepartz, Org. Lett. 2015, 17, 4718-21.

Growth factor identity is encoded by discrete coiled-coil rotamers in the EGFR juxtamembrane region.

Doerner, R. Scheck, & A. Schepartz, Chem. Biol. 2015, 22, 776-784. Highlights: Dialing in EGFR Signaling, Chem. Biol. 2015, 22, 687.

Structural differences between wild-type and double mutant EGFR modulated by third-generation kinase inhibitors.

M.A. Lowder, A.E. Doerner, & A. Schepartz, J. Am. Chem. Soc. 2015, 137, 6456-9. Highlight: SciTechDaily (http://scitechdaily.com/drug-resistant-egfr-may-have-achilles-heel/)

Fluorescence correlation spectroscopy reveals highly efficient cytosolic delivery of certain penta-arg proteins and stapled peptides.

J.R. LaRochelle, G.B. Cobb, A. Steinauer, E. Rhoades, & A. Schepartz, J. Am. Chem. Soc. 2015, 137, 2536-41.

2014

Positive allostery in metal ion binding by a cooperatively folded β-peptide bundle.

J.P. Miller, M.S. Melicher, & A. Schepartz, J. Am. Chem. Soc. 2014, 136, 14726-9.

Influence of macrocyclization on allosteric, juxtamembrane-derived, stapled peptide inhibitors of EGFR.

J.K. Sinclair & A. Schepartz, Org. Lett. 2014, 16, 4916-9.

Inhibiting epidermal growth factor receptor at a distance.

J.K. Sinclair, E.V. Denton, & A. Schepartz, J. Am. Chem. Soc. 2014, 136, 11232-11235. Highlights: F1000 Prime (http://f1000.com/prime/718512057); SciBX (http://www.nature.com/scibx/journal/v7/n35/full/scibx.2014.1036.html)

Interactions of AsCy3 with cysteine-rich peptides.

S.C. Alexander & A. Schepartz, Org. Lett. 2014, 16, 3824-3827.

Hochaufgelöste Visualisierung des Golgi-Apparats in lebenden Zellen mit einem bioorthogonalen Ceramid.

R.S. Erdmann, H. Takakura, A.D. Thompson, F. Rivera-Molina, E.S. Allgeyer, J. Bewersdorf, D.K. Toomre, & A. Schepartz, Angew. Chem. Weinheim. Bergstr. Ger. 2014, 126, 10407-12.

Super-resolution imaging of the Golgi in live cells with a bio-orthogonal ceramide probe.

R.S. Erdmann, H. Takakura, A.D. Thompson, F. Rivera-Molina, E.S. Allgeyer, J. Bewersdorf, D.K. Toomre, & A. Schepartz, Angew. Chem. Int. Ed. Engl. 2014, 53, 10242-6. Highlight: Chosen as a “Hot Paper”.

Chemistry and the BRAIN initiative.

A.M. Andrews, A. Schepartz, J.V. Sweedler, & P.S. Weiss, J. Am. Chem. Soc. 2014, 136, 1-2.

Design and high-resolution structure of a β3-peptide bundle catalyst.

P.S.P. Wang, J.B. Nguyen, & A. Schepartz, J. Am. Chem. Soc. 2014, 136, 6810-6813.

2013

Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics.

J.M. Holub, J.R. LaRochelle, J.S. Appelbaum, & A. Schepartz, Biochemistry 2013, 52, 9036-9046.

Combined lewis acid and bronstead acid-mediated reactivity of glycosyl trichloroacetimidate donors.

N.D. Gould, C.L. Allen, B.C. Nam, A. Schepartz, & S.J. Miller, Carbohydr. Res. 2013, 382, 36-42.

A β-peptide agonist of the GLP-1 receptor, a class B GPCR.

E.V. Denton, C.J. Craig, R.L. Pongratz, J.S. Appelbaum, A.E. Doerner, A. Narayanan, G.I. Shulman, G.W. Cline, & A. Schepartz, Org. Lett. 2013, 15, 5318-5321.

A β-boronopeptide bundle of known structure as a vehicle for polyol recognition.

M.S. Melicher, J. Chu, A.S. Walker, S.J. Miller, R.H.G. Baxter, & A. Schepartz, Org. Lett. 2013, 15, 5048-5051.

Remodeling a β-peptide bundle.

M.A. Molski, J.L. Goodman, F-C. Chou, D. Baker, R. Das, & A. Schepartz, RSC Chem. Sci. 2013, 4, 319-324.

2012

Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm.

J.S. Appelbaum, J.M. LaRochelle, B.A. Smith, D.M. Balkin, J.M. Holub, & A. Schepartz, Chem. Bio. 2012,19, 819-830.

Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation.

R.A. Scheck, M.A. Lowder, J.S. Appelbaum, & A. Schepartz, ACS Chem. Bio. 2012, 7, 1367-1376. Highlight: Faculty of 1000: http://f1000.com/prime/717993412

Relationship between side-chain branching and stoichiometry in β3-peptide bundles.

P.S. Wang, C.J. Craig, & A. Schepartz, Tetrahedron 2012, 68, 4342-4345.

Rewiring kinase specificity with a synthetic adaptor protein.

E.M. Hobert & A. Schepartz, J. Am. Chem. Soc. 2012, 134, 3976-3978. Highlight: Angew. Chem. 2012 (doi: 10.1002/anie.201203345)

2011

Visualizing protein partnerships in living cells and organisms.

M.A. Lowder, J.S. Appelbaum, E.M. Hobert, & A. Schepartz, Curr. Opin. Chem. Biol. 2011, 15, 781-788.

Molecular imaging: sine labore nihil.

A. Schepartz & R.L. Gonzalez Jr., Curr. Opin. Chem. Biol. 2011, 15, 749-751.

Surveying protein structure and function using bis-arsenical small molecules.

R.A. Scheck & A. Schepartz, Acc. Chem. Res. 2011, 44, 654-665.

Enhancing β3-peptide bundle stability by design.

C.J. Craig, J.L. Goodman, & A. Schepartz, ChemBioChem 2011, 12, 1035-1038.

2010

Direct visualization of protein association in living cells with complex-edited electron microscopy.

R.J. Dexter & A. Schepartz, Angew. Chem. 2010, 49, 7952-7954.

β-Peptide bundles with fluorous cores.

M.A. Molski, J.L. Goodman, C.J. Craig, H. Meng, K. Kumar, & A. Schepartz, J. Am. Chem. Soc. 2010, 132, 3658-3659.

Visualizing tyrosine kinase activity with bipartite tetracysteine display.

Visualizing tyrosine kinase activity with bipartite tetracysteine display. S. Ray-Saha & A. Schepartz, ChemBioChem 2010, 11, 2089-2091 95.

β-Peptide bundles with fluorous cores.

M.A. Molski, J.L. Goodman, C.J. Craig, H. Meng, K. Kumar, & A. Schepartz, J. Am. Chem. Soc. 2010, 132, 3658-3659.

Bridged β3-peptide inhibitors of p53-hDM2 complexation: Correlation between affinity and cell permeability.

A.D. Bautista, J.S. Appelbaum, C.J. Craig, J. Michel, & A. Schepartz, J. Am. Chem. Soc. 2010, 132, 2904-2906.

2009

Bipartite tetracysteine display requires site flexibility for ReAsH coordination.

J.L. Goodman, D.B. Fried, & A. Schepartz, ChemBioChem 2009, 10, 1644-1647.

In silico improvement of β3-peptide inhibitors of p53•hDM2 and p53•hDMX.

Michel, E.A. Harker, J. Tirado-Rives, W.L. Jorgensen, & A. Schepartz, J. Am. Chem. Soc. 2009, 131, 6356-6357. Highlight: Nature Chem. 2009 (doi:10.1038/nchem.243)

Cell-permeable β-peptide inhibitors of p53•hDM2 complexation.

E.A. Harker & A. Schepartz, ChemBioChem 2009, 10, 990-993.

Identification of a β3-peptide HIV fusion inhibitor with improved potency in live cells.

A.D. Bautista, O.M. Stephens, L. Wang, R.A. Domaoal, K.S. Anderson, & A. Schepartz, Bioorg. Med. Chem. Lett. 2009, 19, 3736-3738.

β-peptides with improved affinity for hDM2 and hDMX.

E.A. Harker, D.S. Daniels, D.A. Guarracino & A. Schepartz, Bioorg. Med. Chem. 2009, 17, 2038-2046.

Selective recognition of protein tetraserine motifs with a cell-permeable, pro-fluorescent bis-boronic acid.

T.L. Halo, J. Appelbaum, E.M. Hobert, D.M. Balkin, & A. Schepartz, J. Am. Chem. Soc. 2009, 131, 438-439. Highlight: Faculty of 1000 Biology: http://www.f1000biology.com/article/id/1144997/evaluation

2008

Tetrameric β3-peptide bundles.

J.L. Goodman, M.A. Molski, J. Qui, & A. Schepartz, ChemBioChem 2008, 9, 1576-1578.

Minimally cationic cell-permeable miniature proteins via alpha-helical arginine display.

Smith, D.S. Daniels, A. Coplin, G. Jordan, & L. McGregor, & A. Schepartz, J. Am. Chem. Soc. 2008, 130, 2948-2949.

Toward β-amino acid proteins: Design, synthesis, and characterization of a fifteen kilodalton β-peptide tetramer.

E.J. Petersson & A. Schepartz, J. Am. Chem. Soc. 2008, 130, 821-823.

2007

Biophysical and structural characterization of a robust octameric β-peptide bundle.

J.L. Goodman, D.S. Daniels, J.X. Qiu, E.J. Petersson & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 14746-14751.

Intrinsically cell-permeable miniature proteins based on a minimal cationic PPII motif.

D.S. Daniels & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 14578-14579. Highlight: Chem. Eng. News 2007, 85, 43; Highlight: Faculty of 1000 Biology: http://www.f1000biology.com/article/id/1097219/evaluation

Engineering a monomeric miniature protein.

A.M. Hodges & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 11024-11025.

Miniature protein ligands for EVH1 domains: Interplay between affinity, specificity, and cell motility.

J.H. Holtzman, D. Golemi-Kotra, K. Woronowicz & A. Schepartz, Biochemistry 2007, 46, 13541-13553.

Surveying protein conformation and association in live cells with small-molecule fluorescence.

Luedtke, R. Dexter, D. Fried & A. Schepartz, Nat. Chem. Biol. 2007, 3, 779-784. . Highlight: Science 2007, 318, 1217; Highlight: Nat. Methods 2008, 5, 6-7

Biophysical characterization of a β-peptide bundle: Comparison to natural proteins.

E.J. Petersson, C. Craig, D.S. Daniels, J.X. Qiu, & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 1532-1533.

High resolution structure of a β-peptide bundle.

D.S. Daniels, E.J. Petersson, J.X. Qiu, & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 1532-1533. Highlight: Chem. Eng. News 2007, 85(6), 7; Highlight: Chem. Eng. News 2007, 85(52), 13-19; Highlight: Faculty of 1000 Biology: http://www.f1000biology.com/article/id/1071733/evaluation

2006

Encodable activators of Src family kinases.

C.D. Zellefrow, J.S. Griffiths, S. Saha, A.M. Hodges, J.L. Goodman, J. Paulk, J.A. Kritzer & A. Schepartz, J. Am. Chem. Soc. 2006, 128, 16506-16507.

Toward β-amino acid proteins: A cooperatively folded β-peptide quaternary Structure.

J.X. Qiu, E.J. Petersson, E.E. Matthews & A. Schepartz, J. Am. Chem. Soc. 2006, 128, 11338-11339.

Relationship between salt-bridge identity and 14-helix stability of β3-peptides in aqueous buffer.

D.A. Guarracino, H.R. Chiang, T.N. Banks, J.D. Lear, M.E. Hodsdon & A. Schepartz, Org Lett. 2006, 8, 807-810.

Miniature protein inhibitors of the p53•hDM2 interaction.

J.A. Kritzer, R. Zutshi, M. Cheah, F.A. Ran, R. Webman, T.M. Wonjirad & A. Schepartz, ChemBioChem 2006, 7, 29-31.

2005

A Rapid Library Screen for Tailoring β-peptide Structure and Function.

J.A. Kritzer, N.W. Luedtke, E. Harker, & A Schepartz, J. Am. Chem. Soc. 2005, 127, 14584-14585. Highlight: Faculty of 1000: http://www.f1000biology.com/article/id/1028774/evaluation

Inhibiting HIV Fusion with a β-Peptide Foldamer.

O.M. Stephens, S. Kim, B.D. Welch, M.E. Hodsdon, M.S. Kay & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 13126-13127.

Increasing the kinase specificity of K252a by protein surface recognition.

T.L. Schneider, R.S. Mathew, K.P. Rice, K. Tamaki, J.L. Wood & A. Schepartz, Org. Lett. 2005, 7, 1695-1698.

Relationship between folding and function in a sequence-specific miniature DNA-binding protein.

Yang & A. Schepartz, Biochemistry 2005, 44, 7469-7478.

Solution Structure of a β-peptide Ligand for hDM2.

J.A. Kritzer, M.E. Hodsdon & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 4118-4119.

Dephosphorylation of Phosphopeptides by Cerium(IV) and Other Lanthanide Ions.

N.W. Luedtke & A. Schepartz, Chem. Comm. 2005, 43, 5426-5428.

β-peptide inhibitors of protein-protein interactions.

J.A. Kritzer, O.M. Stephens, D.A. Guarracino. S.K. Reznik & A. Schepartz, Bio. Med. Chem. 2005, 13, 11-16.

Binding mode and transcriptional activation potential of high affinity ligands for the CBP KIX domain.

H.M. Volkman, S.E. Rutledge, and A. Schepartz, J. Am. Chem. Soc. 2005, 127, 4649-4658.

Paralog-selective ligands for Bcl-2 proteins.

A.C. Gemperli, S.E. Rutledge, A. Maranda & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 1596-1597.

Relationship between side chain structure and 14-helix stability of β3-peptides in water.

J.A. Kritzer, J. Tirado-Rives, S.A. Hart, J.D. Lear, W.L. Jorgensen, & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 167-178.

2004

Helical β-peptide inhibitors of the p53-hDM2 interaction.

J.A. Kritzer, J.D. Lear, M. Hodsdon & A. Schepartz, J. Am. Chem. Soc. 2004, 126, 9468-9469.

High affinity, paralog-specific recognition of the Mena EVH1 domain by a miniature protein.

Golemi-Kotra, R. Mahaffy, M.J. Footer, J.H. Holtzman, T.D. Pollard, J.A. Theriot & A. Schepartz, J. Am. Chem. Soc. 2004, 126, 4.

2003

Molecular recognition of protein surfaces: High affinity ligands for the CBP KIX domain.

S.E. Rutledge, H. M. Volkman & A. Schepartz, J. Am. Chem. Soc. 2003, 125, 14336.

Helix macrodipole control of β3-peptide 14-helix stability in water.

S.A. Hart, A.B.F. Bahadoor, E.E. Matthews, & A. Schepartz, J. Am. Chem. Soc. 2003, 125, 4022.

Miniature Homeodomains: High specificity without an N-terminal arm.

J.K. Montclare & A. Schepartz, J. Am. Chem. Soc. 2003, 125, 3416.

2002

A View to a Kill: Ligands for Bcl-2 family proteins.

S.E. Rutledge, J.W. Chin & A. Schepartz, Curr. Op. Chem. Biol. 2002, 6, 479-485.

Gal4-VP16 and Gal4-AH increase the orientational and axial specificity of TATA box recognition by TBP.

A.R. Kays & A. Schepartz, Biochemistry 2002, 41, 3147-3155. Highlight: Faculty of 1000: http://www.f1000biology.com/article/id/1006604/evaluation

2001

Electrostatic Control of Half-Site Spacing Preferences by the cyclic AMP Response Element Binding Protein CREB.

J.K. Montclare, L.S. Sloan & A. Schepartz, Nucl. Acids Res. 2001, 29, 3311-3319.

Design and evolution of a miniature Bcl-2 binding protein.

J.W. Chin & A. Schepartz, Angew. Chem. Int. Ed. Eng. 2001, 40, 3806-3809. Highlight: Science 2001, 291, 2049.

Effects of nucleic acids and polyanions on dimer formation and DNA binding by dimeric transcription factors.

J.J. Kohler & A. Schepartz, Bioorg. Med. Chem. 2001, 9, 2435-2443.

Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display.

J.W. Chin, R.M. Grotzfeld, M.A. Fabian & A. Schepartz, Bioorg. Med. Chem. Lett. 2001, 11, 1501-1505.

Hepatitis B Virus protein pX enhances monomer assembly pathway of bZIP•DNA complexes.

T.L. Schneider & A. Schepartz, Biochemistry 2001, 40, 2835-2843.

A Roller Coaster Ride of Thrills.

Schepartz, Chem. Eng. News 2001,125th Anniversary Issue.

Kinetic Preference for Oriented DNA Binding by the Yeast TATA-Binding Protein TBP.

Liu & A. Schepartz, Biochemistry 2001, 40, 6257-6266.

Kinetic studies of Fos•Jun•DNA complex formation: DNA binding prior to dimerization.

J.J. Kohler & A. Schepartz, Biochemistry 2001, 40, 130-142.

Concerted evolution of structure and function in a miniature protein.

J.W. Chin & A. Schepartz, J. Am. Chem. Soc. 2001, 123, 2929-2930.

Hepatitis B virus X protein activates transcription by bypassing CREB phosphorylation, not by stabilizing bZIP-DNA complexes.

M.K. Pflum, D. Hall, T.L. Schneider, & A. Schepartz, Biochemistry 2001, 40, 693-703.

2000

Virtually unidirectional binding of TBP to the AdMLP TATA box within quaternary complex with TFIIA and TFIIB.

A.R. Kays & A. Schepartz, Chem. Biol. 2000, 7, 601-610.

1999

Gene Regulation: Protein escorts to the transcription ball.

J.W. Chin, J.J. Kohler, T.L. Schneider & A. Schepartz, Curr. Biol. 1999, 9, R929-R932.

DNA specificity enhanced by sequential binding of protein monomers.

J.J. Kohler, S.J. Metallo, T.L. Schneider & A. Schepartz, Proc. Natl. Acad. Sci. USA 1999, 96, 11735-11739.

Highly specific DNA recognition by a designed, miniature protein.

N.J. Zondlo & A. Schepartz, J. Am. Chem. Soc. 1999, 121, 6938-6939.

1998

Polarity of transcription on Pol II and archaeal promoters: where is the “one-way sign” and how is it read?

F.T. Tsai, O. Littlefield, P.F. Kosa, J. M. Cox, A. Schepartz & P.B. Sigler, Cold Spring Harb. Symp. Quant. Biol. 1998, 63, 53-61.

At the chemistry-biology interface.

Schepartz & P.S. Kim, Curr. Op. Chem. Biol. 1998, 2, 9-10.

Preinitiation complex assembly: Potentially a bumpy path.

J.M. Cox, A.R. Kays, J.F. Sanchez & A. Schepartz, Curr. Op. Chem. Biol. 1998, 2, 11-17.

Sequence determinants of the intrinsic bend in the cyclic AMP response element.

L.S. Sloan & A. Schepartz, Biochemistry 1998, 37, 7113-7118.

1997

Mechanism of DNA Binding Enhancement by the Hepatitis B Virus Protein X.

C.R. Palmer, L.D. Gegnas, A. Schepartz, Biochemistry 1997, 36, 15349-15355.

Induced DNA bending by the Zn2Cys6 binuclear cluster protein PUT3.

Hoffmann & A. Schepartz, Bio. Med. Chem. Lett. 1997, 7, 2049-2054.

Kinetics and Mechanism of RNA Binding by Triplex Tethered Oligonucleotide Probes.

A.C. Moses & A. Schepartz, J. Am. Chem. Soc. 1997, 119, 11591-11597.

The role of a basic amino acid cluster in target site selection and nonspecific binding of bZIP peptides to DNA.

S.J. Metallo, D.N. Paolella, & A. Schepartz, Nucl. Acids Res. 1997, 25, 2967-2972.

Bidirectional Binding of TBP to the TATA Box.

J.M. Cox, M.H. Hayward, J.F. Sanchez, L.D. Gegnas, S. van der Zee, J.H. Dennis, P.B. Sigler, & A. Schepartz, Proc. Natl. Acad. Sci. USA 1997, 94, 13475-13480.

Electrostatic Mechanism for DNA Bending by bZIP Proteins.

D.N. Paolella, Y. Liu & A. Schepartz, Biochemistry 1997, 36, 10033-10038.

Inhibition of Rev•RRE Complexation by Triplex Tethered Oligonucleotide Probes.

A.C. Moses, S.W. Huang & A. Schepartz, Bioorg. Med. Chem. 1997, 5, 1123-1129.

Certain bZIP Proteins Bind DNA Sequentially as Monomers and Dimerize on the DNA.

S.J. Metallo & A. Schepartz, Nat. Str. Biol. 1997, 4, 115-117.

1996

Triplex Tethered Oligonucleotide Probes.

A.C. Moses & A. Schepartz, J. Am. Chem. Soc. 1996, 118, 10896-10897.

1995

Conformation of Tax-response elements in the human T-cell leukemia virus type I promoter.

J.M. Cox, L.S. Sloan & A. Schepartz, Chem. Biol. 1995, 2, 819-826.

Studies on the Formation of Protein•DNA Interfaces: DNA Specificity and Straightening by CREB.

M.K. Hamm & A. Schepartz, Bio. Med. Chem. Lett. 1995, 5, 1621-1626.

DNA Bending and Binding by Metallo-Peptide Models of bZIP Proteins.

C.R. Palmer, L.S. Sloan, J.C. Adrian, Jr., B. Cuenoud, D.N. Paolella & A. Schepartz, J. Am. Chem. Soc. 1995, 117, 8899-8907.

Mechanism of DNA Binding Enhancement by the HTLV-I Transactivator Tax.

A.M. Baranger, C.R. Palmer, M.K. Hamm, H. A. Giebler, A. Brauweiler, J.K. Nyborg, & A. Schepartz, Nature 1995, 376, 606-608.

Convenient Syntheses of Reagents for Cleavage Mapping Experiments.

M. H. Hayward, J. C. Adrian, Jr. & A. Schepartz, J. Org. Chem. 1995, 60, 3924-3927.

Nonspecific DNA Bending and the Specificity of Protein•DNA Interactions.

Schepartz, Science 1995, 269, 988-989.

Peptide Models of bZIP Proteins: Quantitative Analysis of DNA Affinity and Specificity.

S.J. Metallo & A. Schepartz, Tech. Protein Chem. 1995, 6, 385-391.

Mechanistic Studies on the Formation of bZIP•DNA Interfaces: A Simple Example of Supramolecular Stereochemistry.

D.N. Paolella, C.R. Palmer, S.J. Metallo & A. Schepartz, in Supramolecular Stereochemistry, J. Siegel, Ed. NATO Adv. Ser. 1995, 83-90.

1994

A Uniquely Modified RNA: Site-Specific Introduction of a Single RNA Cleavage Agent into the M1 Ribozyme.

P.L. Richardson, M.L. Gross, R.D. Smith, K.J. Light-Wahl, & A. Schepartz, Bio. Med. Chem. Lett. 1994, 4, 2133-2138.

Distribution of Labor Among CRE-BP1 bZIP Segments in the Control of DNA Affinity and Specificity.

S.J. Metallo & A. Schepartz, Chem. Biol. 1994, 1, 143-152.

Mapping Regions in Eukaryotic Ribosomes that are Accessible to Methidiumpropyl- EDTA•Fe(II) and EDTA•Fe(II).

Han, A. Schepartz, M. Pelligrini & P.B. Dervan, Biochemistry 1994, 33, 9831-9844.

DNA Targets for Certain bZIP Proteins Distinguished by an Intrinsic Bend.

D.N. Paolella, C.R. Palmer & A. Schepartz, Science 1994, 264, 1130-1133.

Selection of Structure-Specific Inhibitors of the HIV Rev–Rev Response Element Complex.

S.T. Cload & A. Schepartz, J. Am. Chem. Soc. 1994, 116, 437-443.

1993

A Kinetic and Thermodynamic Analysis of RNA Binding by Tethered Oligonucleotide Probes: Alternative Structures and Conformational Changes.

S.T. Cload, P.L. Richardson, Y. Huang & A. Schepartz, J. Am. Chem. Soc. 1993, 115, 5005-5014.

1991

A General Scheme for Incorporating Nonnatural Functionality into Peptides.

Cuenoud & A. Schepartz, Tetrahedron Lett. 1991, 32, 3325-3328.

Cuenoud & A. Schepartz, Tetrahedron 1991, 47, 2535-2542.

1990

Site-Specific Cleavage of the Protein Calmodulin Using a Trifluoperazine-Based Affinity Reagent.

Schepartz & B. Cuenoud, J. Am. Chem. Soc. 1990, 112, 3247-3249.

1989

Self-Assembling Ionophores.

Schepartz & J.P. McDevitt, J. Am. Chem. Soc. 1989, 111, 5976-5977.

1987

On the Mechanism of Catalysis by the Enzyme Carboxypeptidase A.

Breslow & A. Schepartz, Chem. Lett. 1987, 1-4.

Hydrolysis of an Amide in a Carboxypeptidase Model Using Co(III) and Bifunctional Catalysts.

Schepartz & R. Breslow, J. Am. Chem. Soc. 1987, 109, 1814-1826.

1983

Substituent Effect on the Electrochemical Oxidation of Arylmethyl Anions. 3. Effect of Methyl Substitution on Diarylmethyl Anions.

Bank, A. Schepartz, P. Giammateo, J. Zubieta, J. Org. Chem. 1983, 48, 3548-3564.